SCHEMBL8072989

SCHEMBL8072989

CCc1ccc(-c2[c]cc(F)cc2F)cc1CC

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 2/20 0.32
ESR2 Q92731 2/20 0.32
PKM P14618 1/20 0.31
RIPK1 Q13546 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8072413 0.79 ESR1 (0.31) ESR1ESR2PKM
SCHEMBL6799098 0.76 ALDH1A1 (0.33)
SCHEMBL8078189 0.75 ESR1 (0.31) ESR1ESR2
SCHEMBL8072992 0.74 ESR1 (0.34) ESR1ESR2
SCHEMBL26036293 0.72 ESR1 (0.44) ESR1ESR2RIPK1
SCHEMBL12488049 0.72 TAAR1 (0.41) ESR2
SCHEMBL10916725 0.71 HSD17B1 (0.45) ESR1ESR2
SCHEMBL8072415 0.70 ALOX5AP (0.32) ESR1ESR2
SCHEMBL8072544 0.70 PKM (0.31) PKMRIPK1
SCHEMBL8066042 0.69 HSD17B1 (0.33) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6166072-A Amino acid derivatives ALLELIX NEUROSCIENCE, INC. (CA) 2000-12-26 US disclosed