SCHEMBL8080072

SCHEMBL8080072

C=CCn1c(C=O)ccc1CO

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.38
ALDH1A1 P00352 3/20 0.37
HPGD P15428 2/20 0.37
KDM4E B2RXH2 2/20 0.37
HSD17B10 Q99714 2/20 0.37
KMT2A Q03164 1/20 0.37
MAPT P10636 4/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP1A2 P05177 1/20 0.33
CYP2D6 P10635 1/20 0.33
POLB P06746 1/20 0.33
ALOX15 P16050 1/20 0.33
HRH1 P35367 1/20 0.31
ADORA2A P29274 1/20 0.30
ADORA2B P29275 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30831892 0.70 POLB (0.43) ALDH1A1KDM4EKMT2AMAPTSMN1; SMN2
SCHEMBL31527830 0.70 ALDH1A1 (0.46) ALDH1A1KMT2A
SCHEMBL6410185 0.70 FABP4 (0.44) ALDH1A1KDM4EHSD17B10KMT2AMAPT
SCHEMBL2807198 0.67 CYP3A4 (0.48) CYP3A4ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL14387230 0.62 LMNA (0.41) CYP3A4ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL6952106 0.62 MAPK1 (0.44) CYP3A4CYP2C19POLBADORA2AADORA2B
SCHEMBL1984602 0.61 MAPK1 (0.40) CYP3A4ALDH1A1HPGDKDM4EHSD17B10
SCHEMBL30523 0.60 TRIM24 (0.45) ALDH1A1KMT2AMAPTCYP1A2POLB
SCHEMBL7675118 0.60 NPC1 (0.39) ALDH1A1KDM4EKMT2AMAPTSMN1; SMN2
SCHEMBL2720779 0.59 RAB9A (0.33) CYP3A4ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0623216-B1 IMMUNOCHEMICAL DETECTION OF $i(IN VIVO) ADVANCED GLYCOSYLATION ENDPRODUCTS UNIV ROCKEFELLER (US) 2000-09-20 EP claimed
US-5733546-A USING AN ANTIBODY TO REACT WITH AN EPITOPE OF THE AGE'S WHICH IS CROSSREACTIVE WITH AGE'S IN VITRO AND NOT WITH OTHER AGE'S SUCH AS PYRRALINE AND PENTOSIDINE THE ROCKEFELLER UNIVERSITY (US) 1998-03-31 US claimed
US-5702704-A Antibodies to in vivo advanced glycosylation endproducts THE ROCKEFELLER UNIVERSITY (US) 1997-12-30 US claimed
US-5683887-A Immunochemical detection of in vivo advanced glycosylation endproducts THE ROCKEFELLER UNIVERSITY (US) 1997-11-04 US claimed
US-5629408-A Immunochemical isolation of in vivo advanced glycosylation endproducts THE ROCKEFELLER UNIVERSITY (US) 1997-05-13 US claimed
US-5624804-A GLYCOSYLATION OF PROTEIN SUCH AS ALBUMIN FOR MEDICAL DIAGNOSIS THE ROCKEFELLER UNIVERSITY (US) 1997-04-29 US claimed
EP-4388016-A1 METHODS AND COMPOSITIONS FOR TREATING FIBROTIC DISEASES Siwa Corporation (US) 2024-06-26 EP disclosed
WO-2024102157-A1 METHODS AND COMPOSITIONS FOR TREATING DIABETES AND DIABETIC COMPLICATIONS SIWA CORPORATION (US) 2024-05-16 WO disclosed
US-11958900-B2 Anti-age antibodies for treating neurodegenerative disorders SIWA CORPORATION (US) 2024-04-16 US disclosed
US-11873345-B2 Product and method for treating sarcopenia SIWA CORPORATION (US) 2024-01-16 US disclosed
US-11872269-B2 Method and composition for treating sarcopenia SIWA CORPORATION (US) 2024-01-16 US disclosed
US-20240000930-A1 METHODS AND COMPOSITIONS FOR TREATING KIDNEY DISEASES SIWA CORP (US) 2024-01-04 US disclosed
US-11833202-B2 Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (AGE) SIWA CORPORATION (US) 2023-12-05 US disclosed
US-5683887-A Immunochemical detection of in vivo advanced glycosylation endproducts THE ROCKEFELLER UNIVERSITY (US) 1997-11-04 US disclosed
US-5629408-A Immunochemical isolation of in vivo advanced glycosylation endproducts THE ROCKEFELLER UNIVERSITY (US) 1997-05-13 US disclosed
US-5624804-A GLYCOSYLATION OF PROTEIN SUCH AS ALBUMIN FOR MEDICAL DIAGNOSIS THE ROCKEFELLER UNIVERSITY (US) 1997-04-29 US disclosed
EP-0688209-A1 GLYCOSYLATION OF LIPIDS AND LIPID-CONTAINING PARTICLES, AND DIAGNOSTIC AND THERAPEUTIC METHODS AND MATERIALS DERIVED THEREFROM THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) 1995-12-27 EP disclosed
EP-0623216-A1 IMMUNOCHEMICAL DETECTION OF $i(IN VIVO) ADVANCED GLYCOSYLATION ENDPRODUCTS THE ROCKEFELLER UNIVERSITY (US) 1994-11-09 EP disclosed
WO-1994020083-A1 GLYCOSYLATION OF LIPIDS AND LIPID-CONTAINING PARTICLES, AND DIAGNOSTIC AND THERAPEUTIC METHODS AND MATERIALS DERIVED THEREFROM THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) 1994-09-15 WO disclosed
WO-1993013421-A1 IMMUNOCHEMICAL DETECTION OF IN VIVO ADVANCED GLYCOSYLATION ENDPRODUCTS THE ROCKEFELLER UNIVERSITY (US) 1993-07-08 WO disclosed