Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | EDNRA | P25101 | 9/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084890 | 0.89 | EDNRA (0.45) | EDNRBALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL8081344 | 0.88 | PTGS2 (0.42) | EDNRBALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL8081905 | 0.85 | ALOX5 (0.45) | EDNRBALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL8085173 | 0.85 | ALDH1A1 (0.46) | EDNRBALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL2954233 | 0.84 | PRKCI (0.49) | EDNRBALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL8086569 | 0.84 | RAB9A (0.44) | EDNRBALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL8072411 | 0.83 | ALDH1A1 (0.42) | EDNRBALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL8072416 | 0.81 | ALDH1A1 (0.42) | EDNRBALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL8081515 | 0.79 | EDNRA (0.45) | EDNRBALDH1A1KDM4EHPGDEDNRA | |
| SCHEMBL8085195 | 0.78 | MAPT (0.45) | EDNRBALDH1A1KDM4EHPGDEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |