Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 5/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287123 | 0.85 | POLB (0.41) | MAPTPOLBMAPK1GABRA5ALDH1A1 | |
| SCHEMBL807788 | 0.81 | EPHX2 (0.35) | POLBMAPK1NPSR1GABRA5DGAT1 | |
| SCHEMBL808346 | 0.79 | POLB (0.33) | MAPTPOLBMAPK1TRPV3NPSR1 | |
| SCHEMBL808036 | 0.77 | POLB (0.34) | MAPTPOLBMAPK1TRPV3NPSR1 | |
| SCHEMBL808244 | 0.77 | HDAC6 (0.34) | — | |
| SCHEMBL15477413 | 0.71 | BACE2 (0.39) | TRPV3NPSR1GABRA5BACE1BACE2 | |
| SCHEMBL10287127 | 0.71 | HDAC8 (0.33) | — | |
| SCHEMBL808332 | 0.69 | GABRA5 (0.34) | POLBMAPK1NPSR1GABRA5 | |
| SCHEMBL10287296 | 0.67 | ATR (0.42) | MAPTPOLBMAPK1ALDH1A1 | |
| SCHEMBL10287533 | 0.66 | ADRA2A (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |