Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | USP28 | Q96RU2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.30 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.30 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097729 | 0.87 | SLC9A1 (0.30) | LMNASLC9A1 | |
| SCHEMBL8088976 | 0.84 | LMNA (0.32) | LMNA | |
| SCHEMBL8350665 | 0.80 | LMNA (0.51) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8358401 | 0.79 | ALDH1A1 (0.42) | LMNAMEN1KMT2AUSP28ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8805378 | 0.79 | LMNA (0.40) | LMNAMEN1KMT2AADRA1DUSP28 | |
| Hydrochloric Acid SCHEMBL8803119 | 0.74 | LMNA (0.57) | LMNAMEN1KMT2AUSP28ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8983516 | 0.73 | SLC9A1 (0.46) | SLC9A1 | |
| SCHEMBL8358558 | 0.68 | LMNA (0.45) | LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL21884475 | 0.68 | LMNA (0.42) | LMNAMEN1KMT2AALDH1A1AVPR2 | |
| SCHEMBL7125185 | 0.68 | TDP1 (0.42) | LMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | claimed |
| JP-10067733-A | — | — | None | — | — | JP | disclosed |
| EP-0814077-B1 | Benzoylguanidines, process for their preparation and medicaments containing them | HOECHST AG (DE) | 2000-04-05 | — | — | EP | disclosed |
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| JP-H1067733-A | ORTHO-SUBSTITUTED BENZOYLGUANIDINE, ITS PRODUCTION, ITS USE AS MEDICINE OR DIAGNOSTIC MEDICINE AND MEDICINE CONTAINING THE SAME | HOECHST AG | 1998-03-10 | — | — | JP | disclosed |
| EP-0814077-A1 | Benzoylguanidines, process for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-29 | — | — | EP | disclosed |