Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358401 | 0.85 | ALDH1A1 (0.42) | LMNAMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8358558 | 0.84 | LMNA (0.45) | LMNAACE2ATMMEN1KMT2A | |
| SCHEMBL8354879 | 0.81 | LMNA (0.42) | LMNAACE2PTGDR2ALDH1A1MAPT | |
| SCHEMBL8089448 | 0.80 | LMNA (0.35) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8805934 | 0.75 | LMNA (0.64) | LMNAKMT2ATSHRPTGDR2ALDH1A1 | |
| SCHEMBL8358390 | 0.72 | ALDH1A1 (0.38) | LMNAMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8358621 | 0.71 | CA2 (0.39) | LMNATSHRALDH1A1CYP2D6MAPT | |
| SCHEMBL34694 | 0.68 | LMNA (1.00) | LMNAMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL8097729 | 0.68 | SLC9A1 (0.30) | LMNA | |
| SCHEMBL27263689 | 0.67 | LMNA (0.56) | LMNAMEN1KMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |