Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | STAT6 | P42226 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097729 | 0.85 | SLC9A1 (0.30) | LMNA | |
| SCHEMBL8089448 | 0.84 | LMNA (0.35) | LMNA | |
| SCHEMBL8358621 | 0.82 | CA2 (0.39) | LMNAADRA2ACYP2D6CYP2C9DRD2 | |
| SCHEMBL8354879 | 0.81 | LMNA (0.42) | LMNA | |
| SCHEMBL8704133 | 0.74 | L3MBTL1 (0.37) | LMNA | |
| SCHEMBL8358390 | 0.71 | ALDH1A1 (0.38) | LMNAADRA2ACYP2D6CYP2C9DRD2 | |
| SCHEMBL8358401 | 0.70 | ALDH1A1 (0.42) | LMNATSHRRORC | |
| Hydrochloric Acid SCHEMBL8983516 | 0.69 | SLC9A1 (0.46) | — | |
| Hydrochloric Acid SCHEMBL8805378 | 0.67 | LMNA (0.40) | LMNA | |
| Hydrochloric Acid SCHEMBL8803119 | 0.67 | LMNA (0.57) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | claimed |
| EP-0814077-B1 | Benzoylguanidines, process for their preparation and medicaments containing them | HOECHST AG (DE) | 2000-04-05 | — | — | EP | disclosed |
| US-6001881-A | Ortho-substituted benzoylguanidines, a process for their preparation, their use as a medicament or diagnostic agent, and a medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |
| EP-0814077-A1 | Benzoylguanidines, process for their preparation and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-29 | — | — | EP | disclosed |