Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.43 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087638 | 0.86 | TAS2R14 (0.50) | TAS2R14HSD11B1LIMK1LIMK2HPGD | |
| SCHEMBL8087753 | 0.85 | TAS2R14 (0.55) | TAS2R14HSD11B1LIMK2LPAR1PTGES | |
| SCHEMBL8092409 | 0.80 | HSD11B1 (0.47) | HSD11B1LIMK1LIMK2RAB9ACA12 | |
| SCHEMBL8090718 | 0.79 | TAS2R14 (0.47) | TAS2R14HSD11B1LIMK1HPGDRAB9A | |
| SCHEMBL8079204 | 0.78 | CNR2 (0.47) | TAS2R14HSD11B1HPGDTDP1NPC1 | |
| SCHEMBL8079261 | 0.78 | HSD11B1 (0.45) | KMT2AHSD11B1LIMK1LIMK2LPAR1 | |
| SCHEMBL8087612 | 0.76 | LPAR1 (0.43) | TAS2R14KMT2AHSD11B1LIMK2LPAR1 | |
| SCHEMBL8086467 | 0.76 | TAS2R14 (0.46) | TAS2R14KMT2AHSD11B1LIMK1HPGD | |
| SCHEMBL8092470 | 0.75 | TAS2R14 (0.49) | TAS2R14LIMK2LPAR1GPR52PTGES | |
| SCHEMBL8087752 | 0.75 | CES2 (0.43) | HSD11B1HPGDNPC1RAB9ACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047670-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036398-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-22 | — | — | WO | disclosed |