Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.43 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 7/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087753 | 0.81 | TAS2R14 (0.55) | LPAR1LPAR5TAS2R14HSD11B1LIMK2 | |
| SCHEMBL8087638 | 0.77 | TAS2R14 (0.50) | TAS2R14SMN1; SMN2HSD11B1LIMK2ALDH1A1 | |
| SCHEMBL8090718 | 0.77 | TAS2R14 (0.47) | TAS2R14SMN1; SMN2HSD11B1ALDH1A1KDM4E | |
| SCHEMBL8090715 | 0.76 | TAS2R14 (0.53) | LPAR1TAS2R14HSD11B1LIMK2MEN1 | |
| SCHEMBL8086467 | 0.76 | TAS2R14 (0.46) | TAS2R14DRD2SMN1; SMN2HSD11B1MEN1 | |
| SCHEMBL8092540 | 0.75 | TAS2R14 (0.50) | LPAR1LPAR5TAS2R14ALDH1A1 | |
| SCHEMBL8092470 | 0.75 | TAS2R14 (0.49) | LPAR1LPAR5TAS2R14LIMK2 | |
| SCHEMBL8092409 | 0.75 | HSD11B1 (0.47) | DRD2SMN1; SMN2HSD11B1LIMK2 | |
| SCHEMBL8087752 | 0.75 | CES2 (0.43) | SMN1; SMN2HSD11B1 | |
| SCHEMBL8079240 | 0.73 | CA12 (0.40) | SMN1; SMN2HSD11B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047670-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036398-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-22 | — | — | WO | disclosed |