Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | BMP1 | P13497 | 1/20 | 0.45 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087753 | 0.90 | TAS2R14 (0.55) | TAS2R14LPAR1LPAR5CTSDBACE1 | |
| SCHEMBL8092540 | 0.88 | TAS2R14 (0.50) | TAS2R14BMP1LPAR1LPAR5PTGES | |
| SCHEMBL8092409 | 0.86 | HSD11B1 (0.47) | ABCB1LIMK2 | |
| SCHEMBL8087708 | 0.82 | TRPM8 (0.45) | — | |
| SCHEMBL8079204 | 0.79 | CNR2 (0.47) | TAS2R14AKR1C3GPR52 | |
| SCHEMBL8079261 | 0.79 | HSD11B1 (0.45) | LPAR1LIMK2 | |
| SCHEMBL6715335 | 0.76 | PTGES (0.60) | AKR1C3LPAR1LPAR5GPR52AOC3 | |
| SCHEMBL8090715 | 0.75 | TAS2R14 (0.53) | TAS2R14LPAR1GPR52PTGESLIMK2 | |
| SCHEMBL8087612 | 0.75 | LPAR1 (0.43) | TAS2R14LPAR1LPAR5LIMK2 | |
| SCHEMBL8086489 | 0.75 | ALDH1A1 (0.49) | BMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047670-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036398-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-22 | — | — | WO | disclosed |