SCHEMBL8087638

SCHEMBL8087638

CCCN(CCC)S(=O)(=O)N(Cc1ccc(C)cc1)C(=O)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TAS2R14 Q9NYV8 2/20 0.50
HSD11B1 P28845 1/20 0.50
POLB P06746 1/20 0.48
CNR2 P34972 6/20 0.48
HDAC1 Q13547 3/20 0.47
HDAC6 Q9UBN7 3/20 0.47
GAA P10253 2/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
HPGD P15428 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
CNR1 P21554 1/20 0.43
LIMK1 P53667 1/20 0.43
LIMK2 P53671 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8079204 0.89 CNR2 (0.47) TAS2R14HSD11B1POLBCNR2HDAC1
SCHEMBL8090715 0.86 TAS2R14 (0.53) TAS2R14HSD11B1HDAC1HDAC6LMNA
SCHEMBL8090718 0.82 TAS2R14 (0.47) TAS2R14HSD11B1HDAC1HDAC6ALDH1A1
SCHEMBL8092409 0.80 HSD11B1 (0.47) HSD11B1HDAC1HDAC6SMN1; SMN2RAB9A
SCHEMBL8087753 0.79 TAS2R14 (0.55) TAS2R14HSD11B1LIMK2
SCHEMBL8086467 0.79 TAS2R14 (0.46) TAS2R14HSD11B1HDAC1HDAC6HPGD
SCHEMBL8079261 0.78 HSD11B1 (0.45) HSD11B1CNR2HDAC1HDAC6LMNA
SCHEMBL8090727 0.78 TRPM8 (0.51) HSD11B1POLBHDAC6ALDH1A1LMNA
SCHEMBL8087752 0.77 CES2 (0.43) HSD11B1CNR2GAAHPGDSMN1; SMN2
SCHEMBL8087612 0.77 LPAR1 (0.43) TAS2R14HSD11B1ALDH1A1SMN1; SMN2LIMK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047670-A1 AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS ELI LILLY AND COMPANY LIMITED (GB) 2000-11-02 EP disclosed
WO-1999036398-A1 AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS ELI LILLY AND COMPANY LIMITED (GB) 1999-07-22 WO disclosed