Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 7/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.47 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.44 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092470 | 0.90 | TAS2R14 (0.49) | TAS2R14PTGESALOX5LIMK2LPAR1 | |
| SCHEMBL8090715 | 0.85 | TAS2R14 (0.53) | TAS2R14PTGESHSD17B2LIMK2HSD11B1 | |
| SCHEMBL8090727 | 0.81 | TRPM8 (0.51) | PTGESHSD11B1 | |
| SCHEMBL8087612 | 0.81 | LPAR1 (0.43) | TAS2R14LIMK2HSD11B1LPAR1LPAR5 | |
| SCHEMBL8092540 | 0.80 | TAS2R14 (0.50) | TAS2R14PTGESALOX5LPAR1LPAR5 | |
| SCHEMBL8087638 | 0.79 | TAS2R14 (0.50) | TAS2R14LIMK2HSD11B1 | |
| SCHEMBL8092409 | 0.77 | HSD11B1 (0.47) | LIMK2HSD11B1 | |
| SCHEMBL8079261 | 0.75 | HSD11B1 (0.45) | LIMK2HSD11B1LPAR1SIGMAR1 | |
| SCHEMBL8090718 | 0.74 | TAS2R14 (0.47) | TAS2R14HSD11B1 | |
| SCHEMBL6783667 | 0.73 | PTGES (0.76) | TAS2R14PTGESALOX5MEP1BHSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047670-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036398-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-22 | — | — | WO | disclosed |