Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.32 |
| ▸ | MTOR | P42345 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095459 | 0.91 | MTOR (0.37) | KMT2APIK3CDMTORPOLBRAB9A | |
| SCHEMBL8091143 | 0.83 | KIF11 (0.36) | KIF11MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL8083616 | 0.82 | ATR (0.42) | KIF11MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL8084965 | 0.81 | IDO1 (0.39) | KIF11MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL8091293 | 0.81 | MAPT (0.42) | KIF11MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL8090868 | 0.80 | MTOR (0.38) | KIF11MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL8091998 | 0.79 | KIF11 (0.40) | KIF11MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL8089537 | 0.79 | KIF11 (0.40) | KIF11MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL8097966 | 0.79 | KIF11 (0.37) | KIF11MEN1HPGDKMT2AALDH1A1 | |
| SCHEMBL8083200 | 0.79 | ALDH1A1 (0.43) | KIF11MEN1KMT2AALDH1A1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |