Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | DHFR | P00374 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HNF4A | P41235 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11089774 | 0.94 | LMNA (0.52) | LMNACALM1IDH1PTPN1PTPN2 | |
| SCHEMBL8085451 | 0.90 | LTA4H (0.43) | LMNACALM1IDH1PTPN1PTPN2 | |
| SCHEMBL8099386 | 0.89 | HTR2A (0.42) | LMNABCL2BCL2L1DHFRALOX5 | |
| SCHEMBL31402539 | 0.87 | BCL2 (0.58) | LMNACALM1IDH1PTPN1PTPN2 | |
| SCHEMBL31402540 | 0.87 | BCL2 (0.58) | LMNACALM1IDH1PTPN1PTPN2 | |
| SCHEMBL8086923 | 0.85 | CALM1 (0.55) | LMNACALM1IDH1PTPN1PTPN2 | |
| SCHEMBL8095678 | 0.85 | CALM1 (0.44) | LMNACALM1IDH1PTPN1PTPN2 | |
| SCHEMBL8771435 | 0.84 | DHFR (0.42) | LMNADHFRHTR2A | |
| SCHEMBL8093674 | 0.84 | TP53 (0.50) | LMNACALM1PTPN1PTPN2PTPN6 | |
| SCHEMBL8098882 | 0.83 | DHFR (0.45) | DHFRTP53LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708077-B1 | Diamino compounds and methods for preparing them | CHISSO CORP (JP) | 2000-12-27 | — | — | EP | disclosed |
| US-5663440-A | Diamino compounds and methods for preparing them | CHISSO CORPORATION (JP) | 1997-09-02 | — | — | US | disclosed |
| EP-0708077-A1 | Diamino compounds and methods for preparing them | CHISSO CORPORATION (JP) | 1996-04-24 | — | — | EP | disclosed |