Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | FBP1 | P09467 | 1/20 | 0.53 |
| ▸ | P4HB | P07237 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL80956 | 1.00 | NFE2L2 (0.56) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL9516761 | 0.86 | NFE2L2 (0.53) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL28853269 | 0.84 | PNMT (0.51) | NFE2L2FBP1 | |
| SCHEMBL19399833 | 0.83 | NFE2L2 (0.50) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL1506009 | 0.82 | NFE2L2 (0.56) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL2095432 | 0.82 | FBP1 (0.57) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL7286051 | 0.82 | NFE2L2 (0.56) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL2095430 | 0.82 | FBP1 (0.57) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL7286044 | 0.82 | NFE2L2 (0.56) | NFE2L2FBP1P4HBMEN1LMNA | |
| SCHEMBL14416283 | 0.82 | NFE2L2 (0.60) | NFE2L2FBP1P4HBMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115716776-A | Method for synthesizing alcohol compound by catalyzing alpha, beta-unsaturated aldehyde | 化学与精细化工广东省实验室 | 2023-02-28 | — | — | CN | claimed |
| CN-107311844-A | The synthesis of m-trifluoromethyl phenylpropanol | 六安佳诺生化科技有限公司 | 2017-11-03 | — | — | CN | claimed |
| US-20120309842-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | RANBAXY LABORATORIES LIMITED (IN) | 2012-12-06 | — | — | US | claimed |
| EP-2477959-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | Ranbaxy Laboratories Limited (IN) | 2012-07-25 | — | — | EP | claimed |
| WO-2011033473-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | RANBAXY LABORATORIES LIMITED (IN) | 2011-03-24 | — | — | WO | claimed |
| WO-2010128388-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF CINACALCET | AUROBINDO PHARMA LIMITED (IN) | 2010-11-11 | — | — | WO | claimed |
| CN-115716776-A | Method for synthesizing alcohol compound by catalyzing alpha, beta-unsaturated aldehyde | 化学与精细化工广东省实验室 | 2023-02-28 | — | — | CN | disclosed |
| US-10202383-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-02-12 | — | — | US | disclosed |
| US-20180291025-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2018-10-11 | — | — | US | disclosed |
| US-10023574-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-07-17 | — | — | US | disclosed |
| US-20180155270-A1 | PROCESS FOR PREPARATION OF CINACALCET INTERMEDIATE AND CINACALCET HYDROCHLORIDE | LUPIN LIMITED (IN) | 2018-06-07 | — | — | US | disclosed |
| US-20180057495-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2018-03-01 | — | — | US | disclosed |
| CN-107311844-A | The synthesis of m-trifluoromethyl phenylpropanol | 六安佳诺生化科技有限公司 | 2017-11-03 | — | — | CN | disclosed |
| WO-2005021500-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |
| US-20040097510-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-05-20 | — | — | US | disclosed |
| US-20030144334-A1 | Cyclopentabenzofuran derivatives and their use | GUARNIERI WALTER (DE) | 2003-07-31 | — | — | US | disclosed |
| US-6420393-B1 | NUCLEAR FACTOR .KAPPA.B-DEPENDENT DISEASE SELECTED FROM THE GROUP CONSISTING OF INFLAMMATORY DISEASES, IMMUNOLOGICAL DISORDERS, SEPTIC SHOCK, TRANSPLANT REJECTION, RADIATION DAMAGE, REPERFUSION INJURIES AFTER ISCHEMIA, STROKE OR | BAYER AKTIENGESELLSCHAFT (DE) | 2002-07-16 | — | — | US | disclosed |
| US-5196422-A | Antiinflammatory agents, antiallergens | ICI PHARMA (FR) | 1993-03-23 | — | — | US | disclosed |
| US-5089513-A | Antiinflammatory agents; antiallergens; asthma; side effect reduction | ICI PHARMA (FR) | 1992-02-18 | — | — | US | disclosed |
| EP-0351194-A2 | Thiazole derivatives having a 5-lipoxygenase-inhibiting activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-01-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202383-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions | DPP8, DPP4, DPP3 | NFE2L2 3306/4885FBP1 542/4885P4HB 981/4885 |
| US-20030144334-A1 | Cyclopentabenzofuran derivatives and their use | NFKBIA, IKBKG, NFKB1 | NFE2L2 17/4885FBP1 1544/4885P4HB 414/4885 |
| US-20120309842-A1 | PROCESSES FOR THE PREPARATION OF CINACALCET | CA4, SI, CA9 | NFE2L2 4330/4885FBP1 1960/4885P4HB 2003/4885 |
| US-20180155270-A1 | PROCESS FOR PREPARATION OF CINACALCET INTERMEDIATE AND CINACALCET HYDROCHLORIDE | SI, ACSL4, C9 | NFE2L2 898/4885FBP1 2339/4885P4HB 2929/4885 |
| US-20180057495-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | DPP8, DPP4, DPP3 | NFE2L2 3306/4885FBP1 542/4885P4HB 981/4885 |
| US-20180291025-A1 | 8-[3-AMINO-PIPERIDIN-1-YL]-XANTHINES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | DPP8, DPP4, DPP3 | NFE2L2 3306/4885FBP1 542/4885P4HB 981/4885 |
| US-20040097510-A1 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions | DPP8, DPP4, DPP3 | NFE2L2 4091/4885FBP1 383/4885P4HB 408/4885 |
| US-10023574-B2 | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions | DPP8, DPP4, DPP3 | NFE2L2 3306/4885FBP1 542/4885P4HB 981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.