Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | NAMPT | P43490 | 3/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096070 | 0.90 | MTOR (0.40) | ATRMTORNAMPTMAOAKMT2A | |
| SCHEMBL8092270 | 0.89 | NPC1 (0.43) | ATRMTORMAPTMEN1KMT2A | |
| SCHEMBL8092294 | 0.87 | ROCK2 (0.39) | ATRMTORNAMPTIGF1RPIK3R1 | |
| SCHEMBL8098135 | 0.86 | MTOR (0.39) | ATRMTORNAMPTIGF1RAKT1 | |
| SCHEMBL8091293 | 0.86 | MAPT (0.42) | ATRMTORNAMPTMAPTMEN1 | |
| SCHEMBL8091129 | 0.86 | KDR (0.40) | ATRGAA | |
| SCHEMBL8091924 | 0.86 | NAMPT (0.39) | ATRNAMPTPIK3CA | |
| SCHEMBL8097714 | 0.85 | NAMPT (0.39) | ATRNAMPTMAPTKMT2AIGF1R | |
| SCHEMBL8098769 | 0.85 | NAMPT (0.39) | ATRNAMPT | |
| SCHEMBL8093540 | 0.84 | RAB9A (0.39) | ATRMTORMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |