Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767162 | 0.93 | LMNA (0.40) | P4HTMLIMK1LIMK2EGFRPTGS2 | |
| SCHEMBL8099328 | 0.91 | P4HTM (0.37) | P4HTMLIMK1KDM4EALDH1A1LIMK2 | |
| SCHEMBL8766943 | 0.86 | PTGS2 (0.48) | P4HTMEGFRPTGS2SCN9APTGS1 | |
| SCHEMBL8096944 | 0.84 | SMN1; SMN2 (0.39) | P4HTMEGFRPTGS2SCN9A | |
| SCHEMBL8097664 | 0.84 | ABL1 (0.37) | P4HTMEGFRPTGS2SCN9A | |
| SCHEMBL8767144 | 0.84 | LMNA (0.38) | P4HTMLIMK1LIMK2EGFRPTGS2 | |
| SCHEMBL8917617 | 0.83 | LIMK1 (0.42) | CA1CA2CA9P4HTMLIMK1 | |
| SCHEMBL8768423 | 0.83 | LMNA (0.41) | P4HTMLIMK1LIMK2EGFRPTGS2 | |
| SCHEMBL8768360 | 0.81 | L3MBTL1 (0.50) | ALDH1A1 | |
| SCHEMBL8768266 | 0.81 | ROCK2 (0.46) | CA1CA2CA9ALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673931-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 1997-08-13 | — | — | EP | disclosed |
| EP-0673931-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides and their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |