Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | MAX | P61244 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767144 | 0.91 | LMNA (0.38) | LMNAHPGDHTTSMN1; SMN2SCN9A | |
| SCHEMBL8096944 | 0.91 | SMN1; SMN2 (0.39) | LMNAHPGDHTTSMN1; SMN2SCN9A | |
| SCHEMBL8875047 | 0.88 | SMN1; SMN2 (0.36) | LMNAHPGDHTTSMN1; SMN2SCN9A | |
| SCHEMBL8106135 | 0.87 | LMNA (0.40) | LMNAHPGDHTTSMN1; SMN2PTGS2 | |
| SCHEMBL8767110 | 0.85 | LMNA (0.40) | LMNAHTTSMN1; SMN2 | |
| SCHEMBL8099328 | 0.84 | P4HTM (0.37) | SMN1; SMN2SCN9APTGS2EGFR | |
| SCHEMBL8097664 | 0.82 | ABL1 (0.37) | LMNAHPGDHTTSMN1; SMN2SCN9A | |
| SCHEMBL8767162 | 0.81 | LMNA (0.40) | LMNAHPGDHTTSMN1; SMN2SCN9A | |
| SCHEMBL8875475 | 0.80 | P4HTM (0.39) | LMNAHPGDHTTSMN1; SMN2PTGS2 | |
| SCHEMBL8097619 | 0.80 | ALDH1A1 (0.41) | LMNAHTTSMN1; SMN2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673932-B1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AG (DE) | 2000-06-07 | — | — | EP | disclosed |
| EP-0673932-A1 | Sulfonamidocarbonyl-pyridine-2-carboxamides as well as their pyridine-N-oxides, process for their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-09-27 | — | — | EP | disclosed |