Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.45 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.45 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9372954 | 0.93 | SIGMAR1 (0.53) | ALDH1A1LMNASMN1; SMN2SIGMAR1MEN1 | |
| SCHEMBL9378564 | 0.91 | SIGMAR1 (0.51) | ALDH1A1SIGMAR1MEN1KMT2APLAAT3 | |
| SCHEMBL8100063 | 0.83 | BCHE (0.58) | SIGMAR1MEN1KMT2A | |
| SCHEMBL9752836 | 0.82 | DRD2 (0.45) | SIGMAR1MEN1KMT2APLAAT3PLAAT5 | |
| SCHEMBL8091780 | 0.80 | SIGMAR1 (0.53) | SIGMAR1MEN1KMT2AL3MBTL1TAAR1 | |
| SCHEMBL8092622 | 0.80 | SIGMAR1 (0.55) | LMNASMN1; SMN2SIGMAR1MEN1KMT2A | |
| SCHEMBL6754066 | 0.79 | MTNR1A (0.48) | SIGMAR1MEN1KMT2ARAB9A | |
| SCHEMBL8099093 | 0.76 | SIGMAR1 (0.52) | SIGMAR1MEN1KMT2AL3MBTL1NPC1 | |
| SCHEMBL8096264 | 0.76 | SIGMAR1 (0.51) | SIGMAR1MEN1KMT2APLAAT3PLAAT5 | |
| SCHEMBL8093024 | 0.76 | SIGMAR1 (0.51) | SIGMAR1MEN1KMT2AL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | claimed |