Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.34 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.34 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8103233 | 0.96 | KDM4E (0.40) | KDM4EGAACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8101317 | 0.88 | KDM4E (0.47) | KDM4EGAACYP1A2POLBMAPT | |
| SCHEMBL8103219 | 0.78 | ADORA3 (0.39) | GAALMNASMN1; SMN2BRD4MEN1 | |
| SCHEMBL8107634 | 0.77 | PKM (0.37) | KDM4EGAACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8101460 | 0.76 | PKM (0.36) | KDM4EGAACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7468232 | 0.74 | ADRA2A (0.33) | L3MBTL1LMNASMN1; SMN2BRD4MEN1 | |
| SCHEMBL8101312 | 0.74 | HTR1A (0.39) | KDM4ECYP1A2CYP2C19POLBMAPT | |
| SCHEMBL8101320 | 0.73 | CYP2D6 (0.40) | KDM4ECYP1A2CYP2C19POLBMAPT | |
| SCHEMBL8101449 | 0.72 | MYC (0.40) | GAAL3MBTL1LMNASMN1; SMN2MEN1 | |
| SCHEMBL8103434 | 0.69 | ADRA2A (0.34) | LMNASMN1; SMN2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |