Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.55 |
| ▸ | MMP12 | P39900 | 3/20 | 0.55 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | MMP14 | P50281 | 1/20 | 0.55 |
| ▸ | MMP15 | P51511 | 1/20 | 0.55 |
| ▸ | MMP16 | P51512 | 1/20 | 0.55 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8114344 | 0.84 | MMP2 (0.73) | MMP2MMP12MMP9MMP14MMP15 | |
| SCHEMBL1629814 | 0.83 | MMP2 (0.57) | MMP2MMP12MMP9MMP14MMP15 | |
| SCHEMBL8120164 | 0.82 | MMP2 (0.71) | MMP2MMP12MMP9MMP14MMP15 | |
| SCHEMBL25645644 | 0.82 | TSHR (0.63) | MMP2MMP12MMP9MMP14MMP15 | |
| Water SCHEMBL28896308 | 0.81 | MMP2 (0.56) | MMP2MMP12MMP9MMP14MMP15 | |
| SCHEMBL6054597 | 0.78 | MMP2 (0.53) | MMP2MMP12MMP9MMP14MMP15 | |
| SCHEMBL1828579 | 0.77 | MAPT (0.54) | MMP2MMP12MMP9MMP14MMP15 | |
| SCHEMBL4202509 | 0.77 | MMP2 (0.51) | MMP2MMP12MMP9MMP14MMP15 | |
| SCHEMBL8881262 | 0.77 | MMP2 (0.51) | MMP2MMP12MMP9MMP14MMP15 | |
| Potassium Ion SCHEMBL8104536 | 0.76 | TSHR (0.59) | NPC1MAPTMAPK1HTTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6126855-A | Reaction products of lyotropic liquid crystal salt complexes | ELLIOTT STANLEY B (US) | 2000-10-03 | — | — | US | disclosed |
| US-5833877-A | DIAGMAGNETIC COMPLEX; SUPERCONDUCTORS | ELLIOTT STANLEY B (US) | 1998-11-10 | — | — | US | disclosed |
| US-5595683-A | COMPLEX OF METAL SALT OF BENZOYLPROPIONIC ACID, LATTICE MODIFIER, CYCLIZATION, HUMIDITY SENSORS | ELLIOTT STANLEY B (US) | 1997-01-21 | — | — | US | disclosed |
| US-5443753-A | Reaction products of lyotropic liquid crystal salt complexes | ELLIOTT STANLEY B (US) | 1995-08-22 | — | — | US | disclosed |
| US-5354499-A | Reaction products of lyotropic liquid crystal salt complexes | ELLIOTT STANLEY B (US) | 1994-10-11 | — | — | US | disclosed |
| US-5354496-A | Lyotropic liquid crystal salt/inorganic compound complexation products | ELLIOTT STANLEY B (US) | 1994-10-11 | — | — | US | disclosed |