Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | SGK1 | O00141 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8082685 | 0.93 | IDO1 (0.40) | IDO1TDO2ALDH1A1PIK3CAMTOR | |
| SCHEMBL8083416 | 0.90 | PIK3R1 (0.39) | IDO1TDO2ALDH1A1PIK3CANAMPT | |
| SCHEMBL8084965 | 0.89 | IDO1 (0.39) | IDO1TDO2ALDH1A1PIK3CAMTOR | |
| SCHEMBL8083200 | 0.87 | ALDH1A1 (0.43) | IDO1TDO2ALDH1A1PIK3CAMTOR | |
| SCHEMBL8084961 | 0.87 | NAMPT (0.41) | PIK3CAMTORPIK3CGNAMPTHDAC3 | |
| SCHEMBL8100133 | 0.87 | NAMPT (0.41) | PIK3CAMTORPIK3CGNAMPTHDAC3 | |
| SCHEMBL8093534 | 0.86 | NAMPT (0.41) | PIK3CAMTORPIK3CGNAMPTHDAC3 | |
| SCHEMBL8097966 | 0.85 | KIF11 (0.37) | IDO1TDO2ALDH1A1PIK3CAMTOR | |
| SCHEMBL8090834 | 0.85 | KIF11 (0.35) | IDO1TDO2ALDH1A1MEN1IKBKB | |
| SCHEMBL8084982 | 0.84 | KIF11 (0.38) | IDO1TDO2ALDH1A1NAMPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |