Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 6/20 | 0.47 |
| ▸ | MMP2 | P08253 | 5/20 | 0.47 |
| ▸ | FPR2 | P25090 | 3/20 | 0.44 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5020188 | 0.83 | MMP13 (0.47) | MMP13MMP2FPR2PROKR1TEAD1 | |
| SCHEMBL6096681 | 0.71 | FPR2 (0.61) | MMP13MMP2FPR2PROKR1MMP12 | |
| SCHEMBL4788541 | 0.70 | FPR2 (0.48) | MMP13MMP2FPR2PROKR1TEAD1 | |
| SCHEMBL8777604 | 0.69 | FPR2 (0.48) | MMP13MMP2FPR2PROKR1TEAD1 | |
| SCHEMBL7398293 | 0.67 | MMP13 (0.55) | MMP13MMP2FPR2PROKR1TEAD1 | |
| SCHEMBL5020541 | 0.67 | HRH1 (0.47) | FPR2PROKR1 | |
| SCHEMBL7764828 | 0.67 | MMP13 (0.78) | MMP13MMP2FPR2PROKR1TEAD1 | |
| SCHEMBL6098249 | 0.67 | FPR2 (0.56) | MMP13MMP2FPR2PROKR1TEAD1 | |
| SCHEMBL8096418 | 0.66 | FPR2 (0.46) | MMP13FPR2PROKR1MMP12RAB9A | |
| SCHEMBL3222147 | 0.66 | EPHX2 (0.58) | MMP13MMP2FPR2PROKR1TEAD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147764-A1 | MMP INHIBITORS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA, INC. (US) | 2008-12-04 | — | — | WO | disclosed |