Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8124141 | 0.89 | RAB9A (0.39) | KAT8PKMHTTALDH1A1PPARA | |
| SCHEMBL8124637 | 0.85 | RAB9A (0.44) | PKMHTTALDH1A1SENP7CASP3 | |
| SCHEMBL8109251 | 0.84 | KAT8 (0.38) | KAT8PKMTRPM8ALDH1A1PPARA | |
| SCHEMBL8123575 | 0.83 | FBP1 (0.43) | PKMALDH1A1SENP7CASP3SENP8 | |
| SCHEMBL8126318 | 0.80 | PKM (0.40) | KAT8PKMHTTALDH1A1PPARA | |
| SCHEMBL8119109 | 0.80 | ALOX15 (0.41) | KAT8PKMTRPM8ALDH1A1SENP7 | |
| SCHEMBL8125598 | 0.78 | PTPN1 (0.48) | ALDH1A1SENP7CASP3SENP6LMNA | |
| SCHEMBL8124340 | 0.76 | KAT8 (0.44) | KAT8HTTTRPM8ALDH1A1PPARA | |
| SCHEMBL8118002 | 0.75 | HPGD (0.48) | PKMHTTALDH1A1LMNAMAPT | |
| SCHEMBL8124527 | 0.75 | PTPRB (0.43) | KAT8PKMTRPM8LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036069-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999028306-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |