SCHEMBL812586

SCHEMBL812586

O=C1CCC(=O)N1Sc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.52
HSD17B10 Q99714 2/20 0.52
ALDH1A1 P00352 2/20 0.52
PARL Q9H300 4/20 0.41
RAB9A P51151 6/20 0.37
NPC1 O15118 5/20 0.37
MEN1 O00255 2/20 0.37
KMT2A Q03164 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.36
HPGD P15428 1/20 0.36
MGLL Q99685 1/20 0.36
DDB1 Q16531 1/20 0.34
CRBN Q96SW2 1/20 0.34
PKM P14618 1/20 0.34
ALOX12 P18054 1/20 0.34
POLB P06746 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20503175 0.81 ALDH1A1 (0.43) MAPTHSD17B10ALDH1A1RAB9ANPC1
SCHEMBL11569738 0.78 MEN1 (0.41) MAPTHSD17B10ALDH1A1RAB9ANPC1
SCHEMBL7341984 0.78 CRBN (0.39) MAPTHSD17B10ALDH1A1RAB9ANPC1
SCHEMBL11090245 0.78 CRBN (0.39) MAPTALDH1A1RAB9ANPC1MEN1
SCHEMBL28539505 0.78 ALDH1A1 (0.38) MAPTHSD17B10ALDH1A1RAB9ANPC1
SCHEMBL28493477 0.78 FAAH (0.38) MAPTHSD17B10ALDH1A1MGLL
SCHEMBL7337733 0.78 CRBN (0.39) MAPTHSD17B10ALDH1A1RAB9AMEN1
SCHEMBL1165632 0.78 MAPT (0.44) MAPTHSD17B10ALDH1A1PARLRAB9A
SCHEMBL1041075 0.78 MAPT (0.41) MAPTHSD17B10ALDH1A1PARLRAB9A
SCHEMBL31599173 0.77 ALDH1A1 (0.39) MAPTHSD17B10ALDH1A1MGLLPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12492220-B2 Method for the preparation of oligonucleotides THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2025-12-09 US claimed
CN-118598736-A Synthesis method of alpha, beta-unsaturated carbonyl compound 中山大学 2024-09-06 CN claimed
CN-118515585-A Synthesis method of alkenyl cyanide compound 中山大学 2024-08-20 CN claimed
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV (CA) 2023-06-22 US claimed
US-12492220-B2 Method for the preparation of oligonucleotides THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2025-12-09 US disclosed
CN-118598736-A Synthesis method of alpha, beta-unsaturated carbonyl compound 中山大学 2024-09-06 CN disclosed
CN-118515585-A Synthesis method of alkenyl cyanide compound 中山大学 2024-08-20 CN disclosed
CN-106922129-B Methods of conjugating polypeptides 免疫医疗有限责任公司 2024-02-20 CN disclosed
CN-117165966-A Method for constructing N-thioether substituted sulfoxide imine derivative through electrochemical promotion 桂林理工大学 2023-12-05 CN disclosed
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV (CA) 2023-06-22 US disclosed
US-11548910-B2 Oligonucleotide production method NISSAN CHEMICAL CORPORATION (JP) 2023-01-10 US disclosed
CN-113683548-B Preparation method of 3, 4-dithiopyrrole material 太原理工大学 2022-12-27 CN disclosed
EP-0052299-A1 2-Oxoazetidine derivatives and production thereof Takeda Chemical Industries, Ltd. (JP) 1982-05-26 EP disclosed
US-4283508-A Fragrant prevulcanization inhibitors MONSANTO COMPANY (US) 1981-08-11 US disclosed
US-4278686-A ANTIBIOTICS BEECHAM GROUP LIMITED (GB) 1981-07-14 US disclosed
EP-0005914-A1 Chemical process for the preparation of beta-lactamase inhibitors, and so obtained compounds BEECHAM GROUP PLC (GB) 1979-12-12 EP disclosed
EP-0005348-A1 Carbapenem derivatives, a process for their preparation and pharmaceutical compositions containing them BEECHAM GROUP PLC (GB) 1979-11-14 EP disclosed
EP-0005349-A1 Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates BEECHAM GROUP PLC (GB) 1979-11-14 EP disclosed
US-4119780-A 2(Isopropyldithio)benzimidazole MONSANTO COMPANY (US) 1978-10-10 US disclosed
US-4006155-A Method for preparation of phosphorus polysulfides MONSANTO COMPANY (US) 1977-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11548910-B2 Oligonucleotide production method RNGTT, OSGEP, PHAX MAPT 3183/4885HSD17B10 1121/4885ALDH1A1 3610/4885
US-12492220-B2 Method for the preparation of oligonucleotides POLN, POLRMT, POLI MAPT 3637/4885HSD17B10 4366/4885ALDH1A1 4284/4885
US-20230192751-A1 METHOD FOR THE PREPARATION OF OLIGONUCLEOTIDES POLN, POLRMT, POLI MAPT 3637/4885HSD17B10 4366/4885ALDH1A1 4284/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.