Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28919283 | 0.81 | LMNA (0.57) | EDNRBEDNRA | |
| SCHEMBL6026448 | 0.81 | HSD11B1 (0.56) | SCN9AHSD11B1 | |
| SCHEMBL8110606 | 0.80 | HSD11B1 (0.48) | SCN9AHSD11B1 | |
| SCHEMBL8111406 | 0.79 | ALDH1A1 (0.60) | SCN9AEDNRA | |
| SCHEMBL8125378 | 0.79 | LMNA (0.44) | SCN9AGPR119EDNRBEDNRA | |
| SCHEMBL5228000 | 0.79 | GPR119 (0.54) | GPR119 | |
| SCHEMBL5228220 | 0.77 | PTPN2 (0.58) | — | |
| SCHEMBL1951129 | 0.77 | LTA4H (0.49) | GPR119EDNRBEDNRALTA4H | |
| SCHEMBL8108924 | 0.77 | FBP1 (0.71) | — | |
| SCHEMBL5228131 | 0.76 | PSEN1 (0.52) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036069-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-20 | — | — | EP | claimed |
| WO-1999028306-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | claimed |
| EP-1036069-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999028306-A1 | BENZENESULFONAMIDE COMPOUNDS | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-06-10 | — | — | WO | disclosed |