Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 9/20 | 0.50 |
| ▸ | MMP13 | P45452 | 9/20 | 0.50 |
| ▸ | MMP2 | P08253 | 9/20 | 0.50 |
| ▸ | MMP3 | P08254 | 8/20 | 0.50 |
| ▸ | MMP1 | P03956 | 7/20 | 0.50 |
| ▸ | MMP7 | P09237 | 7/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8283226 | 0.84 | MMP2 (0.68) | ADAMTS4CA12CA14MMP9MMP13 | |
| SCHEMBL690201 | 0.84 | MMP2 (0.68) | ADAMTS4CA12CA14MMP9MMP13 | |
| SCHEMBL690202 | 0.84 | MMP2 (0.68) | ADAMTS4CA12CA14MMP9MMP13 | |
| SCHEMBL1656188 | 0.84 | ADAMTS4 (0.76) | ADAMTS4MMP9MMP13MMP2MMP3 | |
| SCHEMBL8283227 | 0.84 | ADAMTS4 (0.76) | ADAMTS4MMP9MMP13MMP2MMP3 | |
| SCHEMBL6723663 | 0.81 | MMP9 (0.72) | ADAMTS4CA12CA14CA9MMP9 | |
| SCHEMBL6723666 | 0.81 | MMP9 (0.72) | ADAMTS4CA12CA14CA9MMP9 | |
| SCHEMBL7347163 | 0.81 | MMP9 (0.72) | ADAMTS4CA12CA14CA9MMP9 | |
| SCHEMBL9595462 | 0.81 | MMP1 (0.53) | CA12CA14CA7CA9MMP9 | |
| SCHEMBL5899567 | 0.81 | MMP9 (0.61) | ADAMTS4CA12CA14MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543858-B1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARM (GB) | 2000-12-20 | — | — | EP | disclosed |
| US-5451676-A | Treatment of hypotension and bronchoconstriction | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-09-19 | — | — | US | disclosed |
| US-5274094-A | Diseases or conditions mediated by platelet-activating factor; cyclization of a diamino compound with a carboxylic acid | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-12-28 | — | — | US | disclosed |
| EP-0543858-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| US-5200412-A | Antiinflammatory agents and antiallergens | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-04-06 | — | — | US | disclosed |
| WO-1992003423-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |