Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Phenylpiperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 known ✓ | P08588 | 4/20 | 0.71 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.53 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.50 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.50 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.50 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.50 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.71 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.71 |
| ▸ | HTR3B | O95264 | 3/20 | 0.71 |
| ▸ | HTR3A | P46098 | 3/20 | 0.71 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.71 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylpiperazine SCHEMBL8141187 | 1.00 | SIGMAR1 (0.71) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL3866046 | 1.00 | SIGMAR1 (0.71) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL3866050 | 1.00 | SIGMAR1 (0.71) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL11621472 | 0.89 | ADRB1 (0.83) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL2002893 | 0.85 | ADRB1 (0.77) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL24889 | 0.84 | ADRB1 (1.00) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL29135595 | 0.84 | ADRB1 (1.00) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL27858598 | 0.84 | ADRB1 (1.00) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Phenylpiperazine SCHEMBL55125 | 0.84 | ADRB1 (1.00) | SIGMAR1ADRB1HTR3EHTR3BHTR3A | |
| Fumaric Acid SCHEMBL27454231 | 0.83 | CHRNB2 (0.67) | SIGMAR1ADRB1HTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003739-A2 | 2-(4-ARYL OR HETEROARYL-PIPERAZIN-1-YLMETHYL)-1H-INDOLE DERIVATIVES | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999009025-A2 | 2-(4-ARYL OR HETEROARYL-PIPERAZIN-1-YLMETHYL)-1H-INDOLE DERIVATIVES INTERACTING WITH THE DOPAMINE D4 RECEPTOR | PFIZER PRODUCTS INC. (US) | 1999-02-25 | — | — | WO | disclosed |