SCHEMBL8147516

SCHEMBL8147516

O=C(C1=C(c2ccc(N(c3ccccc3)c3ccccc3)cc2)C(=O)c2ccccc2C1=O)c1ccccc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.75
MEN1 O00255 4/20 0.75
KMT2A Q03164 4/20 0.75
NPSR1 Q6W5P4 4/20 0.75
SMN1; SMN2 Q16637 3/20 0.75
ALDH1A1 P00352 3/20 0.75
XBP1 P17861 2/20 0.75
HKDC1 Q2TB90 2/20 0.75
L3MBTL1 Q9Y468 2/20 0.75
HSP90AA1 P07900 7/20 0.51
HSP90AB1 P08238 5/20 0.51
MAPT P10636 4/20 0.47
TDP1 Q9NUW8 4/20 0.47
NPC1 O15118 3/20 0.47
RAB9A P51151 3/20 0.47
MAPK1 P28482 3/20 0.47
HTT P42858 3/20 0.47
KDM4E B2RXH2 2/20 0.47
MPI P34949 2/20 0.47
FGFR1 P11362 6/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8147517 0.88 LMNA (0.69) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL5390429 0.86 ALDH1A1 (1.00) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL17969765 0.82 MEN1 (0.79) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL17969764 0.82 LMNA (0.73) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL30885094 0.81 LMNA (0.88) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL7099523 0.80 MEN1 (0.75) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL17969757 0.78 MEN1 (0.71) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL17969761 0.77 LMNA (0.66) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL21470360 0.77 MEN1 (0.79) LMNAMEN1KMT2ANPSR1SMN1; SMN2
SCHEMBL7099261 0.76 LMNA (0.73) LMNAMEN1KMT2ANPSR1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2000191608-A NAPHTHOQUINONE DERIVATIVE AND ELECTROPHOTOGRAPHIC RECEPTOR CONTAINING THE SAME KYOCERA MITA CORP 2000-07-11 JP disclosed