Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 9/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 6/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8168017 | 0.91 | MEN1 (0.35) | HCAR3PTGER1GBA1CYP1A2CCR5 | |
| SCHEMBL8703967 | 0.84 | CCR5 (0.48) | HCAR3RXRAPTGER1RXRBCYP1A2 | |
| SCHEMBL8701112 | 0.83 | CCR5 (0.46) | HCAR3RXRAPTGER1CYP1A2CCR5 | |
| SCHEMBL1907786 | 0.83 | RXRA (0.53) | HCAR3RXRAPTGER1CYP1A2CCR5 | |
| SCHEMBL7672615 | 0.82 | HCAR3 (0.51) | HCAR3RXRAGBA1PPARG | |
| SCHEMBL8162210 | 0.81 | ALDH1A1 (0.45) | HCAR3RXRAPTGER1CYP1A2CCR5 | |
| SCHEMBL8167622 | 0.81 | GAA (0.48) | HCAR3RXRAPTGER1GBA1CYP1A2 | |
| SCHEMBL8167606 | 0.81 | CCR5 (0.58) | RXRAPTGER1CCR5 | |
| SCHEMBL7673319 | 0.80 | RXRA (0.56) | HCAR3RXRAPTGER1RXRBRXRG | |
| SCHEMBL7974626 | 0.79 | HCAR3 (0.46) | HCAR3RXRAGBA1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773930-B1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LTD (GB) | 2000-10-11 | — | — | EP | disclosed |
| US-5843942-A | Aromatic amino ethers as pain relieving agents | ZENECA LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |