Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | ICMT | O60725 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | KRAS | P01116 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679351 | 0.85 | ALDH1A1 (0.62) | ALDH1A1LMNAPLA2G4AICMTPLA2G2A | |
| SCHEMBL9236079 | 0.82 | CDC25A (0.70) | CDC25ACNR1CNR2ICMT | |
| SCHEMBL20769653 | 0.79 | ALDH1A1 (0.61) | CDC25AMCL1TBXAS1ALDH1A1LMNA | |
| SCHEMBL8176472 | 0.79 | ALDH1A1 (0.55) | CNR2ALDH1A1LMNAPLA2G4AICMT | |
| SCHEMBL10696722 | 0.77 | CNR2 (0.49) | CDC25ACNR1CNR2TBXAS1ALDH1A1 | |
| SCHEMBL8171661 | 0.77 | LMNA (0.75) | ALDH1A1LMNAPLA2G4AICMTPLA2G2A | |
| SCHEMBL8179565 | 0.77 | ICMT (0.58) | ALDH1A1LMNAPLA2G4AICMTPLA2G2A | |
| SCHEMBL4668108 | 0.75 | TBXAS1 (0.44) | MCL1CNR1CNR2TBXAS1ALDH1A1 | |
| SCHEMBL8175259 | 0.75 | PPARD (0.66) | ALDH1A1LMNALTB4RLTB4R2ICMT | |
| SCHEMBL8174648 | 0.74 | PLA2G2A (0.61) | ALDH1A1LMNAICMTPLA2G2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-02-19 | — | — | US | disclosed |
| WO-2008100867-A2 | NOVEL INHIBITORS HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090047246-A1 | NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION | EIF2AK2, HAVCR2, HCCS | CDC25A 315/4885MCL1 2836/4885CNR1 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.