Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 6/20 | 0.35 |
| ▸ | HTR1A | P08908 | 5/20 | 0.35 |
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.33 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8177078 | 0.91 | ADRA1A (0.35) | SLC6A4HTR2AHTR1ADRD2ADRA2A | |
| SCHEMBL8175851 | 0.90 | KAT2B (0.33) | SLC6A4HTR2AHTR1ADRD2ADRA2A | |
| SCHEMBL9139885 | 0.88 | HTR1A (0.33) | SLC6A4HTR2AHTR1ADRD2KAT2B | |
| SCHEMBL8186216 | 0.84 | SLC6A4 (0.36) | SLC6A4KAT2BSLC6A2SLC6A3 | |
| SCHEMBL8185153 | 0.83 | ADRA1A (0.49) | SLC6A4HTR2AHTR1ADRD2ADRA2A | |
| SCHEMBL8804674 | 0.81 | CARM1 (0.34) | HTR2ADRD2ADRA2AADRA2BADRA2C | |
| SCHEMBL9138352 | 0.81 | BACE1 (0.37) | SLC6A4HTR2AHTR1ADRD2ADRA2A | |
| SCHEMBL9139815 | 0.80 | PTGS2 (0.34) | ADRA2AADRA2BADRA2CADRA1AKAT2B | |
| SCHEMBL8804858 | 0.80 | CYP2D6 (0.36) | SLC6A4HTR2AHTR1ADRD2ADRA2A | |
| SCHEMBL9138413 | 0.78 | DRD3 (0.40) | DRD2ADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028073-A | N-substituted 3-azabicyclo (3.2.0)heptane derivatives useful as neuroleptics | BASF AKTIENGESELLSCHAFT (DE) | 2000-02-22 | — | — | US | disclosed |
| EP-0775135-A1 | N-SUBSTITUTED 3-AZABICYCLO (3.2.0)HEPTANE DERIVATIVES USEFUL AS NEUROLEPTICS | BASF AKTIENGESELLSCHAFT (DE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004272-A1 | N-SUBSTITUTED 3-AZABICYCLO (3.2.0)HEPTANE DERIVATIVES USEFUL AS NEUROLEPTICS | BASF AKTIENGESELLSCHAFT (DE) | 1996-02-15 | — | — | WO | disclosed |