Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4397299 | 0.77 | ALDH1A1 (0.35) | KDM4EALDH1A1TDP1HPRT1 | |
| SCHEMBL3052569 | 0.75 | ALOX15 (0.31) | KDM4EALDH1A1TDP1HSD17B10 | |
| SCHEMBL6680764 | 0.72 | HPRT1 (0.38) | KDM4EALDH1A1TDP1HSD17B10HPRT1 | |
| SCHEMBL27858602 | 0.70 | ALDH1A1 (0.37) | KDM4EALDH1A1TDP1HSD17B10HPRT1 | |
| SCHEMBL2639252 | 0.69 | ALDH1A1 (0.37) | KDM4EALDH1A1TDP1HSD17B10HPRT1 | |
| SCHEMBL9010837 | 0.69 | ALDH1A1 (0.35) | KDM4EALDH1A1TDP1HSD17B10HPRT1 | |
| SCHEMBL7037922 | 0.68 | ALDH1A1 (0.36) | KDM4EALDH1A1TDP1HSD17B10HPRT1 | |
| SCHEMBL454682 | 0.68 | ALDH1A1 (0.71) | KDM4EALDH1A1TDP1HSD17B10HPRT1 | |
| SCHEMBL16513160 | 0.65 | ALDH1A1 (0.34) | KDM4EALDH1A1TDP1HSD17B10HPRT1 | |
| SCHEMBL4404534 | 0.65 | ALDH1A1 (0.34) | KDM4EALDH1A1TDP1HSD17B10HPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6086871-A | PROTHROMBIN MUTANT HAVING BINDING CAPACITY TO HIRUDIN, HEPARIN, AND ANTITHROMBIN; SPECIFIC REPLACEMENTS OR DELETIONS IN THEIR AMINO ACID SEQUENCES, AND AN ACTIVITY OF NO MORE THAN 0.25% OF THROMBIN; ANTICOAGULANT SIDE EFFECT REDUCTION | BAXTER AKTIENGESELLSCHAFT (AT) | 2000-07-11 | — | — | US | disclosed |
| WO-1998037898-A1 | SYNERGISTICALLY ACTING ANTI-FUNGAL AGENTS THAT ARE INHIBITORS OF FOLATE METABOLISM, ESPECIALLY METHOTREXATE AND SULFAMETHOXAZOLE | BARCLAY BARRY J (CA) | 1998-09-03 | — | — | WO | disclosed |