SCHEMBL8196440

SCHEMBL8196440

CC1(C)C=C(c2cccnc2)c2cc(C#N)ccc2O1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 9/20 0.46
CYP11B1 P15538 7/20 0.46
CYP17A1 P05093 1/20 0.46
CYP19A1 P11511 2/20 0.42
CHRNB2 P17787 3/20 0.41
CHRNA5 P30532 3/20 0.41
CHRNA4 P43681 3/20 0.41
NPY5R Q15761 1/20 0.38
ABCC9 O60706 1/20 0.37
BACE1 P56817 1/20 0.37
KCNH2 Q12809 1/20 0.37
NEK1 Q96PY6 1/20 0.37
FLT3 P36888 2/20 0.37
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9088354 0.85 ABCC9 (0.38) CYP11B2CYP11B1CYP19A1ABCC9BACE1
SCHEMBL8195282 0.85 OPRD1 (0.44) CYP19A1ABCC9KCNH2
SCHEMBL8797782 0.84 CYP11B2 (0.40) CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2
SCHEMBL8311321 0.84 CYP11B2 (0.44) CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2
SCHEMBL9524863 0.80 CLK4 (0.40) ABCC9
SCHEMBL9478589 0.79 CYP11B2 (0.46) CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2
SCHEMBL8085127 0.78 CYP11B2 (0.36) CYP11B2CYP11B1CYP17A1CYP19A1CHRNB2
SCHEMBL9084957 0.78 RAB9A (0.46) CYP11B2CYP11B1CYP19A1CHRNB2CHRNA5
SCHEMBL9525005 0.77 GABRA1 (0.38) CYP11B2CYP11B1CYP17A1ABCC9BACE1
SCHEMBL8332841 0.77 METAP2 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2000078724-A2 IMIDAZOLINDERIVATIVES THEIR PREPARATION AND THEIR PHARMACEUTICAL USE ELI LILLY AND COMPANY (US) 2000-12-28 WO disclosed
US-5493029-A USEFUL IN TREATING ASTHMA AND HYPERTENSION KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1996-02-20 US disclosed
US-5300511-A Spiro-benzopyran derivatives and useful for treating asthma and hypertension KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1994-04-05 US disclosed
EP-0298452-B1 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL F. HOFFMANN-LA ROCHE AG (CH) 1993-06-30 EP disclosed
EP-0514942-A1 Novel benzopyran derivatives and processes for the preparation thereof KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1992-11-25 EP disclosed
US-5118694-A Hypotensive agents; treatment for cardiovascular and muscular disorders HOFFMANN-LA ROCHE INC. (US) 1992-06-02 US disclosed
US-4971982-A HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS HOFFMANN-LA ROCHE INC. (US) 1990-11-20 US disclosed
CN-1030582-A 1-benzopyran derivatives HOFFMANN LA ROCHE (CH) 1989-01-25 CN disclosed
EP-0298452-A2 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl F. HOFFMANN-LA ROCHE AG (CH) 1989-01-11 EP disclosed