Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203967 | 0.78 | CYP2D6 (0.35) | PTGS2 | |
| SCHEMBL8192460 | 0.75 | PTGS2 (0.40) | PTGS2PTGS1TRPV1 | |
| SCHEMBL8206064 | 0.74 | ALKBH3 (0.36) | PTGS2PTGS1 | |
| SCHEMBL8200749 | 0.74 | ALDH1A1 (0.34) | — | |
| SCHEMBL8201217 | 0.72 | PTGS2 (0.48) | PTGS2PTGS1 | |
| SCHEMBL8204972 | 0.71 | ALDH1A1 (0.34) | PTGS2TRPV1 | |
| SCHEMBL12570860 | 0.65 | AKR1C3 (0.45) | AKR1C3AKR1C2PGR | |
| SCHEMBL8205670 | 0.65 | PTGS2 (0.34) | PTGS2AKR1C3AKR1C2PTGS1PGR | |
| SCHEMBL13377328 | 0.64 | PGR (0.41) | PTGS2AKR1C3AKR1C2ALOX5APFEN1 | |
| SCHEMBL8206097 | 0.64 | CYP2D6 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6140344-A | FOR TREATING PATHOLOGICAL CONDITIONS SUCH AS ASTHMA, RHINITIS, ECZEMA AND PARASITIC INFECTIONS FEATURING TISSUE EOSINOPHILIA | SYNTEX (U.S.A.) INC. (US) | 2000-10-31 | — | — | US | disclosed |