Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 15/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200188 | 0.87 | KDM4E (0.44) | MEN1KMT2ASLC18A3HTR2C | |
| SCHEMBL8203690 | 0.86 | PRCP (0.42) | PRCPCCR5SLC18A3HTR2C | |
| SCHEMBL8200402 | 0.84 | HTR2C (0.48) | PRCPCHRM3CCR5SLC18A3HTR2C | |
| SCHEMBL8200675 | 0.84 | HTR2C (0.49) | PRCPCHRM3MEN1ALDH1A1KMT2A | |
| SCHEMBL8198484 | 0.83 | HTR2C (0.42) | MEN1KMT2ASLC18A3HTR2C | |
| SCHEMBL8200595 | 0.83 | ALDH1A1 (0.45) | MEN1ALDH1A1KMT2AATMCCR5 | |
| SCHEMBL8199345 | 0.82 | CCR2 (0.46) | CCR5HTR2C | |
| SCHEMBL8199643 | 0.82 | CCR5 (0.48) | PRCPCCR5SLC18A3HTR2C | |
| SCHEMBL8589678 | 0.82 | SIGMAR1 (0.44) | MEN1KMT2AHTR2C | |
| SCHEMBL8588349 | 0.82 | SIGMAR1 (0.44) | MEN1KMT2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | disclosed |