Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203549 | 0.87 | HTR2C (0.43) | ALDH1A1KDM4ETSHRNPSR1MEN1 | |
| SCHEMBL8200188 | 0.84 | KDM4E (0.44) | KDM4EMEN1KMT2ASMN1; SMN2HTR2C | |
| SCHEMBL8200414 | 0.83 | PRCP (0.44) | ALDH1A1ATMCCR5MEN1KMT2A | |
| SCHEMBL8199643 | 0.81 | CCR5 (0.48) | CCR5HTR2C | |
| SCHEMBL8200402 | 0.78 | HTR2C (0.48) | CCR5HTR2C | |
| SCHEMBL8199345 | 0.78 | CCR2 (0.46) | CCR5HTR2C | |
| SCHEMBL8191618 | 0.78 | HTR2C (0.50) | ALDH1A1MAPTKDM4ECCR5POLB | |
| SCHEMBL8198484 | 0.77 | HTR2C (0.42) | TSHRMEN1KMT2AHTR2C | |
| SCHEMBL8192538 | 0.77 | PRCP (0.56) | ALDH1A1KDM4ELMNAHPGDHSD17B10 | |
| SCHEMBL8199832 | 0.77 | PRCP (0.56) | ALDH1A1KDM4ELMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |