Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14825200 | 0.84 | TSHR (0.49) | CYP3A4MRGPRX4TSHRHTR2AHTR2C | |
| SCHEMBL4289243 | 0.83 | CYP3A4 (0.45) | PTGDR2CYP3A4EPAS1TRPV4TSHR | |
| SCHEMBL12434789 | 0.79 | TP53 (0.48) | CYP3A4MRGPRX4TSHRSMN1; SMN2TDP1 | |
| SCHEMBL11959678 | 0.79 | TSHR (0.49) | TSHRHTR2BSMN1; SMN2TDP1CYP1A2 | |
| SCHEMBL15031950 | 0.78 | HTR3E (0.45) | MRGPRX4TRPV4KDM4ESLC6A4MEN1 | |
| SCHEMBL15031545 | 0.78 | TTR (0.46) | MRGPRX4TRPV4TDP1SLC6A4KCNH2 | |
| SCHEMBL17752348 | 0.78 | MAOB (0.42) | CYP3A4TSHRHTR2BSMN1; SMN2ALOX15 | |
| SCHEMBL12918470 | 0.77 | MAPT (0.53) | MRGPRX4TSHRSMN1; SMN2TDP1TP53 | |
| SCHEMBL26191596 | 0.76 | TDP1 (0.37) | TSHRSMN1; SMN2TDP1TP53LMNA | |
| SCHEMBL5422262 | 0.74 | CYP3A4 (0.48) | CYP3A4TSHRHTR2ASMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180051021-A1 | BICYCLIC KETONE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2018-02-22 | — | — | US | disclosed |
| US-20180053903-A1 | Organic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device | SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) | 2018-02-22 | — | — | US | disclosed |
| US-9458152-B2 | Bicyclic sulfonamide compounds as sodium channel inhibitors | AMGEN INC. (US) | 2016-10-04 | — | — | US | disclosed |
| US-9212182-B2 | Bicyclic sulfonamide compounds as sodium channel inhibitors | AMGEN INC. (US) | 2015-12-15 | — | — | US | disclosed |
| US-20140371201-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. | 2014-12-18 | — | — | US | disclosed |
| US-20140058106-A1 | SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2014-02-27 | — | — | US | disclosed |
| US-20110054175-A1 | SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180053903-A1 | Organic Compound, Light-Emitting Element, Light-Emitting Device, Electronic Device, and Lighting Device | AOX1, RECQL, SQOR | PTGDR2 1476/4885CYP3A4 387/4885MRGPRX4 1009/4885 |
| US-20140058106-A1 | SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS | PFAS, ODC1, AOC1 | PTGDR2 3762/4885CYP3A4 886/4885MRGPRX4 3381/4885 |
| US-20140371201-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | SCN7A, TRPV1, TRPV5 | PTGDR2 1659/4885CYP3A4 1804/4885MRGPRX4 448/4885 |
| US-20180051021-A1 | BICYCLIC KETONE SULFONAMIDE COMPOUNDS | TRPV1, TRPA1, KCNJ11 | PTGDR2 2084/4885CYP3A4 993/4885MRGPRX4 798/4885 |
| US-20110054175-A1 | SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS | PFAS, ODC1, AOC1 | PTGDR2 3762/4885CYP3A4 886/4885MRGPRX4 3381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.