Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 6/20 | 0.32 |
| ▸ | MAOB | P27338 | 6/20 | 0.32 |
| ▸ | KDM1A | O60341 | 4/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.32 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13532274 | 1.00 | RECQL (0.34) | RECQLHDAC4TSHRSLC18A3MAOA | |
| SCHEMBL9370820 | 0.67 | CHRM2 (0.47) | — | |
| SCHEMBL8497209 | 0.65 | ALDH1A1 (0.36) | RECQLHDAC4SLC18A3LMNA | |
| SCHEMBL16226181 | 0.65 | TSHR (0.37) | TSHRSLC18A3MAOAMAOBKDM1A | |
| SCHEMBL7054926 | 0.63 | ALOX15 (0.37) | SLC18A3 | |
| SCHEMBL447032 | 0.59 | SLC18A3 (0.63) | TSHRSLC18A3CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL19198566 | 0.59 | SLC18A3 (0.63) | TSHRSLC18A3CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL1616696 | 0.59 | PABPC1 (0.38) | CYP2B6CYP1A2CYP2C9LMNASLC6A2 | |
| SCHEMBL790829 | 0.59 | SLC18A3 (0.63) | TSHRSLC18A3CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL42833 | 0.59 | SLC18A3 (0.63) | TSHRSLC18A3CYP2C19CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541593-B2 | Process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541593-B2 | Process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8536345-B2 | Process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8536345-B2 | Process for making substituted 2-amino-thiazolones | AMGEN INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20110160463-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. | 2011-06-30 | — | — | US | disclosed |
| US-20100280255-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | AMGEN INC. (US) | 2010-11-04 | — | — | US | disclosed |
| WO-2007113309-A2 | COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF | GLAXO GROUP LIMITED (GB) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280255-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | HSD11B1, HSD11B2, HSD17B1 | RECQL 427/4885HDAC4 1016/4885TSHR 1338/4885 |
| US-20110160463-A1 | PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES | HSD11B1, HSD11B2, HSD17B1 | RECQL 489/4885HDAC4 957/4885TSHR 1236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.