Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | AQP1 | P29972 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256849 | 0.90 | PARP1 (0.34) | HTR1ACDK2CDK9HTR7NOTUM | |
| SCHEMBL8259987 | 0.85 | HTR1A (0.35) | HTR1ACDK2CDK9HTR7 | |
| SCHEMBL8248843 | 0.83 | LMNA (0.36) | HTR1ACDK2CDK9PARP1GAA | |
| SCHEMBL8259066 | 0.82 | ALDH1A1 (0.36) | HTR7GAAKMT2A | |
| SCHEMBL8258142 | 0.82 | XDH (0.35) | CDK2CDK9NOTUMPARP1 | |
| SCHEMBL8256879 | 0.79 | AQP1 (0.47) | HTR1AAQP1NOTUMPARP1 | |
| SCHEMBL8254801 | 0.78 | HTR1A (0.36) | HTR1ACDK2CDK9AQP1NOTUM | |
| SCHEMBL15319473 | 0.74 | PARP1 (0.41) | HTR1ANOTUMPARP1 | |
| SCHEMBL30543420 | 0.74 | PARP1 (0.41) | HTR1ANOTUMPARP1 | |
| SCHEMBL8248841 | 0.73 | XDH (0.34) | HTR1AAQP1NOTUMPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006116165-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |