Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | FURIN | P09958 | 1/20 | 0.38 |
| ▸ | GNPAT | O15228 | 2/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | PADI1 | Q9ULC6 | 2/20 | 0.35 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.35 |
| ▸ | PADI2 | Q9Y2J8 | 2/20 | 0.35 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.35 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22359335 | 0.86 | GNPAT (0.50) | ALBCHRM2CHRM4CHRM1SIRT6 | |
| SCHEMBL14951121 | 0.82 | NOD1 (0.32) | NOD1 | |
| SCHEMBL10064609 | 0.82 | NOD1 (0.34) | SIRT5ALBNOD1PDE4APDE4B | |
| SCHEMBL12961585 | 0.81 | SIRT5 (0.51) | SIRT5ALBCHRM2CHRM4CHRM1 | |
| SCHEMBL14951733 | 0.80 | GNPAT (0.34) | GNPATNOD1 | |
| SCHEMBL14295763 | 0.80 | NOD1 (0.33) | SIRT5NOD1 | |
| SCHEMBL468949 | 0.79 | KISS1R (0.36) | NOD1KISS1R | |
| SCHEMBL16299579 | 0.79 | NOD1 (0.32) | SIRT5NOD1 | |
| SCHEMBL24520157 | 0.78 | SIRT6 (0.50) | SIRT5ALBCHRM2CHRM4CHRM1 | |
| SCHEMBL3933327 | 0.78 | SIRT6 (0.50) | SIRT5ALBCHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003756-A1 | C5a Receptor Antagonists | JERINI AG (DE) | 2011-01-06 | — | — | US | disclosed |
| US-7727960-B2 | C5a receptor antagonists | JERINI AG (DE) | 2010-06-01 | — | — | US | disclosed |
| US-7727960-B2 | C5a receptor antagonists | JERINI AG (DE) | 2010-06-01 | — | — | US | disclosed |
| US-20080161232-A1 | C5a is a cleavage product of the complement cascade, the CS convertase; antiinflammatory agents; autoimmune diseases; cyclic peptide compounds | JERINI AG (DE) | 2008-07-03 | — | — | US | disclosed |
| WO-2006074964-A1 | C5A RECEPTOR ANTAGONISTS | JERINI AG (DE) | 2006-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003756-A1 | C5a Receptor Antagonists | C5AR1, C3AR1, C5AR2 | SIRT5 2059/4885ALB 1303/4885CHRM2 33/4885 |
| US-20080161232-A1 | C5a is a cleavage product of the complement cascade, the CS convertase; antiinflammatory agents; autoimmune diseases; cyclic peptide compounds | C3AR1, C5, C5AR1 | SIRT5 2845/4885ALB 1538/4885CHRM2 67/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.