Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532334 | 0.83 | ALDH1A1 (0.42) | MMP13ALDH1A1TSPOCES2CES1 | |
| SCHEMBL21894123 | 0.80 | MMP13 (0.50) | MMP13ALDH1A1TSPOFFAR1FFAR4 | |
| SCHEMBL2794479 | 0.77 | ALOX15 (0.47) | ALDH1A1CES2CES1L3MBTL1MEN1 | |
| SCHEMBL4309806 | 0.73 | BACE1 (0.40) | FFAR1FFAR4 | |
| SCHEMBL3046764 | 0.73 | L3MBTL1 (0.75) | ALDH1A1MAOBMAOAL3MBTL1MAPT | |
| SCHEMBL8257779 | 0.72 | CYP3A4 (0.45) | MMP13ALDH1A1MAOAGAAFFAR1 | |
| SCHEMBL1879154 | 0.71 | PKM (0.69) | ALDH1A1L3MBTL1GAA | |
| SCHEMBL4536231 | 0.71 | TDP1 (0.62) | ALDH1A1MAOAL3MBTL1MAPTMEN1 | |
| SCHEMBL17466069 | 0.71 | CES2 (0.44) | ALDH1A1CES2CES1MAOBMAOA | |
| SCHEMBL17324196 | 0.70 | GAA (0.67) | ALDH1A1CES2CES1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756087-B1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH CORP (US) | 2009-10-07 | — | — | EP | disclosed |
| WO-2006009653-A1 | AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE | WYETH (US) | 2006-01-26 | — | — | WO | disclosed |