Sugi Predict

Sugi Predict / Compounds / Fenyripol

Fenyripol

Fenyripol

SCHEMBL828783

OC(CNc1ncccn1)c1ccccc1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CYP2D6 P10635 1/20 0.70
▸ KDM4E B2RXH2 2/20 0.57
▸ L3MBTL1 Q9Y468 1/20 0.57
▸ AOC3 Q16853 3/20 0.53
▸ HPGD P15428 1/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ NPC1 O15118 2/20 0.48
▸ HTT P42858 1/20 0.47
▸ BCAT2 O15382 1/20 0.47
▸ ADRB2 P07550 1/20 0.46
▸ RAB9A P51151 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ FAAH O00519 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fenyripol SCHEMBL120829 0.98 CYP2D6 (0.68) CYP2D6KDM4EL3MBTL1AOC3HPGD
SCHEMBL5596789 0.82 CYP2D6 (0.54) CYP2D6KDM4EL3MBTL1AOC3HPGD
SCHEMBL2874311 0.82 ALDH1A1 (0.48) CYP2D6KDM4EHPGDNPC1RAB9A
Phenyramidol SCHEMBL21963 0.82 CYP2D6 (1.00) CYP2D6KDM4EL3MBTL1AOC3HTT
Phenyramidol SCHEMBL13310219 0.82 CYP2D6 (1.00) CYP2D6KDM4EL3MBTL1AOC3HTT
Phenyramidol SCHEMBL13310227 0.82 CYP2D6 (1.00) CYP2D6KDM4EL3MBTL1AOC3HTT
Phenyramidol SCHEMBL29500950 0.82 CYP2D6 (1.00) CYP2D6KDM4EL3MBTL1AOC3HTT
SCHEMBL6674136 0.82 HIF1A (0.59) CYP2D6KDM4EADRB2RAB9A
Phenyramidol SCHEMBL20769334 0.81 CYP2D6 (0.97) CYP2D6KDM4EL3MBTL1AOC3HTT
Phenyramidol SCHEMBL29375712 0.81 CYP2D6 (0.97) CYP2D6KDM4EL3MBTL1AOC3HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 177 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2961730-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XenoPort, Inc. (US) 2016-01-06 — — EP claimed
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2015-06-11 — — US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 — — US claimed
WO-2014134005-A2 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-09-04 — — WO claimed
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS XENOPORT, INC. (US) 2014-08-28 — — US claimed
CN-101486668-B Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof XENOPORT INC 2014-07-02 — — CN claimed
US-8299291-B2 Methods of synthesizing 1-(acyloxy)-alkyl carbamate prodrugs XENOPORT, INC. (US) 2012-10-30 — — US claimed
US-8062870-B2 Enantiomerically resolving acyloxyalkyl thiocarbonates used in synthesizing acyloxyalkyl carbamate prodrugs XENOPORT, INC. (US) 2011-11-22 — — US claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 — — US claimed
US-7662987-B2 Oxidation of 1-acyl alkyl compound under anhydrous condition XENOPORT, INC. (US) 2010-02-16 — — US claimed
US-7560483-B2 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof XENOPORT, INC. (US) 2009-07-14 — — US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 — — CN claimed
US-20080255073-A1 COMPOUNDS FOR SUSTAINED RELEASE OF ORALLY DELIVERED DRUGS XONOPORT, INC. (US) 2008-10-16 — — US claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 — — EP claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 — — US claimed
US-20050239725-A1 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof XENOPORT, INC. 2005-10-27 — — US claimed
US-6927036-B2 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof XERO PORT, INC. (US) 2005-08-09 — — US claimed
US-5684018-A Acyloxyisopropyl carbamates as prodrugs for amine drugs MERCK & CO., INC. (US) 1997-11-04 — — US claimed
WO-1996018605-A1 ACYLOXYISOPROPYL CARBAMATES AS PRODRUGS FOR AMINE DRUGS MERCK & CO., INC. (US) 1996-06-20 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080255073-A1 COMPOUNDS FOR SUSTAINED RELEASE OF ORALLY DELIVERED DRUGS ABCB11, ABCB1, SLC10A1 CYP2D6 94/4885KDM4E 4131/4885L3MBTL1 4383/4885
US-20150158809-A9 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA CYP2D6 124/4885KDM4E 180/4885L3MBTL1 3853/4885
US-20140243544-A1 METHOD OF MAKING 1-(ACYLOXY)-ALKYL CARBAMATE COMPOUNDS CPS1, CA7, NAAA CYP2D6 124/4885KDM4E 180/4885L3MBTL1 3853/4885
US-20050239725-A1 Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof AADAC, UGT1A1, ABHD5 CYP2D6 23/4885KDM4E 1022/4885L3MBTL1 1169/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.