Sugi Predict

Sugi Predict / Compounds / SCHEMBL829971

SCHEMBL829971

SCHEMBL829971

CCOC(=O)COc1ccc(NC(C)=O)cc1

nearest known ligand 0.71

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.71
▸ MEN1 O00255 2/20 0.71
▸ LMNA P02545 1/20 0.71
▸ CYP1A2 P05177 1/20 0.71
▸ TDP1 Q9NUW8 1/20 0.71
▸ MAPT P10636 4/20 0.65
▸ RAB9A P51151 2/20 0.65
▸ GAA P10253 1/20 0.59
▸ NPSR1 Q6W5P4 1/20 0.59
▸ EPHX2 P34913 1/20 0.58
▸ ALDH1A1 P00352 4/20 0.57
▸ HTT P42858 1/20 0.57
▸ HSD17B10 Q99714 1/20 0.57
▸ L3MBTL1 Q9Y468 1/20 0.53
▸ POLB P06746 1/20 0.53
▸ PPID Q08752 1/20 0.53
▸ SMN1; SMN2 Q16637 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL831304 0.86 MAPT (0.59) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL22192691 0.85 NPC1 (0.65) KMT2ALMNACYP1A2MAPTRAB9A
SCHEMBL7309018 0.84 GAA (0.62) LMNAMAPTGAANPSR1EPHX2
SCHEMBL25505702 0.84 LMNA (0.65) KMT2AMEN1LMNACYP1A2TDP1
Phenacetin SCHEMBL23280 0.83 KMT2A (1.00) KMT2AMEN1LMNACYP1A2TDP1
Phenacetin SCHEMBL18894356 0.83 KMT2A (1.00) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL3295760 0.83 GAA (0.60) LMNAMAPTGAANPSR1EPHX2
SCHEMBL4860756 0.83 GAA (0.60) LMNAMAPTGAANPSR1EPHX2
SCHEMBL4856473 0.82 EPHX2 (0.54) KMT2AMEN1LMNACYP1A2TDP1
SCHEMBL3059908 0.82 SMN1; SMN2 (0.65) KMT2AMEN1LMNACYP1A2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113248596-B Artificial antigen and antibody capable of simultaneously detecting acetaminophen and phenacetin, and preparation method and application thereof 华南农业大学 2022-12-16 — — CN disclosed
CN-113248596-A Artificial antigen and antibody capable of simultaneously detecting acetaminophen and phenacetin, and preparation method and application thereof 华南农业大学 2021-08-13 — — CN disclosed
US-20190083482-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2019-03-21 — — US disclosed
US-20190083482-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2019-03-21 — — US disclosed
EP-3406607-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2018-11-28 — — EP disclosed
US-20180162847-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2018-06-14 — — US disclosed
US-20180162847-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2018-06-14 — — US disclosed
US-20180162847-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2018-06-14 — — US disclosed
EP-2935243-B1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF EPIZYME INC (US) 2018-03-14 — — EP disclosed
EP-2935243-B1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF EPIZYME INC (US) 2018-03-14 — — EP disclosed
WO-2007030538-A2 FUNCTIONALIZED DRUGS AND POLYMERS DERIVED THEREFROM BEZWADA BIOMEDICAL LLC (US) 2007-03-15 — — WO disclosed
WO-2007030538-A2 FUNCTIONALIZED DRUGS AND POLYMERS DERIVED THEREFROM BEZWADA BIOMEDICAL LLC (US) 2007-03-15 — — WO disclosed
US-20060188547-A1 Bioabsorbable and biocompatible polyurethanes and polyamides for medical devices BEZWADA BIOMEDICAL, LLC (US) 2006-08-24 — — US disclosed
US-20060172983-A1 Functionalized drugs and polymers derived therefrom BEZWADA BIOMEDICAL, LLC (US) 2006-08-03 — — US disclosed
US-20060173065-A1 Functionalized phenolic esters and amides and polymers therefrom BEZWADA BIOMEDICAL LLC 2006-08-03 — — US disclosed
US-4387099-A Alkanolamine derivatives IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1983-06-07 — — US disclosed
US-4327113-A DRUGS FOR TREATMENT OF HEART DISEASES, ADRENERGIC BLOCKING AGENTS, ETC IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1982-04-27 — — US disclosed
US-4260632-A ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1981-04-07 — — US disclosed
US-4221807-A ADRENERGIC BLOCKING AGENTS IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1980-09-09 — — US disclosed
US-4141987-A HYPOTENSIVE, ADRENERGIC BLOCKING AGENT IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) 1979-02-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060172983-A1 Functionalized drugs and polymers derived therefrom OGFR, LOX, OPRM1 KMT2A 3676/4885MEN1 4307/4885LMNA 1845/4885
US-20190083482-A1 PRMT5 INHIBITORS AND USES THEREOF PRMT5, PRMT1, PRMT6 KMT2A 58/4885MEN1 1329/4885LMNA 2468/4885
US-20060173065-A1 Functionalized phenolic esters and amides and polymers therefrom HAAO, HAO2, HCAR3 KMT2A 2066/4885MEN1 4878/4885LMNA 3626/4885
US-20180162847-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF PRMT5, PRMT1, PRMT3 KMT2A 35/4885MEN1 1238/4885LMNA 2702/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.