Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10894517 | 0.84 | ELANE (0.45) | MAPK1MAPTPOLBKCNH2NPSR1 | |
| SCHEMBL11578594 | 0.77 | LMNA (0.45) | MAPK1MAPTPOLBNR1I2MEN1 | |
| SCHEMBL2044409 | 0.77 | ELANE (0.42) | MAPK1MAPTPOLBNPSR1NR1I2 | |
| SCHEMBL905941 | 0.76 | ELANE (0.49) | MAPTKMT2AHPGDALOX15ACHE | |
| SCHEMBL5849992 | 0.75 | ALDH1A1 (0.53) | MAPK1MAPTPOLBKMT2ATSHR | |
| SCHEMBL16601102 | 0.75 | ALOX15 (0.49) | MAPK1MAPTPOLBMEN1KMT2A | |
| SCHEMBL8467275 | 0.74 | ELANE (0.47) | MAPK1MAPTPOLBMEN1KMT2A | |
| SCHEMBL6915874 | 0.74 | MAPK1 (0.48) | MAPK1MAPTPOLBNPSR1NR1I2 | |
| SCHEMBL1305579 | 0.73 | POLB (0.59) | MAPK1MAPTPOLBKCNH2NPSR1 | |
| SCHEMBL577685 | 0.73 | CES2 (0.44) | MAPTPOLBMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912511-A1 | 5-INDOLYL-2,4-PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | Smithkline Beecham S.p.A. (IT) | 1999-05-06 | — | — | EP | disclosed |
| WO-1998001423-A1 | 5-INDOLYL-2,4-PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION | SMITHKLINE BEECHAM S.P.A. (IT) | 1998-01-15 | — | — | WO | disclosed |