Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304291 | 0.82 | SIGMAR1 (0.46) | SLC6A4SIGMAR1HTR1ADRD4MC4R | |
| SCHEMBL8303444 | 0.82 | SIGMAR1 (0.55) | SIGMAR1KMT2AHTR2BCCR3 | |
| SCHEMBL8303871 | 0.80 | OPRM1 (0.42) | SIGMAR1HTR1ACCR3 | |
| SCHEMBL8304636 | 0.79 | OPRM1 (0.41) | HRH3SLC6A4HTR1ACCR3DRD4 | |
| SCHEMBL8303188 | 0.78 | HTR2B (0.33) | SIGMAR1HTR1AHTR2BCCR3DRD4 | |
| SCHEMBL9178363 | 0.76 | SIGMAR1 (0.41) | SLC6A4SIGMAR1HTR1AHTR2BCCR3 | |
| SCHEMBL9143193 | 0.75 | DRD2 (0.39) | SLC6A4HTR1ACCR3DRD4 | |
| SCHEMBL8303201 | 0.74 | SIGMAR1 (0.43) | SIGMAR1HTR2BCCR3 | |
| SCHEMBL9175467 | 0.74 | SIGMAR1 (0.40) | SLC6A4SIGMAR1HTR1ACCR3SLC6A2 | |
| SCHEMBL8303556 | 0.74 | SIGMAR1 (0.43) | SIGMAR1KMT2AHTR2BCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | claimed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | claimed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | claimed |
| EP-0574313-B1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR (FR) | 1999-10-06 | — | — | EP | disclosed |
| US-5464834-A | Antidepressants, central nervous system | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0574313-A1 | 1,4-Disubstituted piperazines for the treatment of disorders of the central nervous system and neuro-endocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-12-15 | — | — | EP | disclosed |