Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GPR4 | P46093 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8423969 | 0.90 | KDM1A (0.43) | KDM1AGPR119MAPTALDH1A1POLB | |
| SCHEMBL2381764 | 0.82 | ADORA1 (0.42) | L3MBTL1 | |
| SCHEMBL26125344 | 0.79 | MEN1 (0.40) | GPR119MEN1KMT2A | |
| SCHEMBL5767328 | 0.77 | ADORA1 (0.39) | L3MBTL1MEN1KMT2AGPR4 | |
| SCHEMBL7831653 | 0.76 | PKM (0.53) | L3MBTL1KDM1AGPR119MEN1KMT2A | |
| SCHEMBL16490799 | 0.76 | MEN1 (0.47) | L3MBTL1GPR119MEN1KMT2AMAPT | |
| SCHEMBL7831649 | 0.76 | GPR119 (0.49) | KDM1AGPR119MEN1KMT2AMAPT | |
| SCHEMBL7831085 | 0.76 | ALDH1A1 (0.50) | KDM1AGPR119MEN1KMT2AALDH1A1 | |
| SCHEMBL7974238 | 0.75 | L3MBTL1 (0.47) | L3MBTL1KDM1AGPR119MEN1KMT2A | |
| SCHEMBL7839366 | 0.75 | GPR119 (0.48) | L3MBTL1KDM1AGPR119MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965578-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0897303-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-02-24 | — | — | EP | disclosed |
| EP-0897303-A4 | — | — | 1999-02-24 | — | — | EP | disclosed |
| WO-1997036605-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |