Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302750 | 0.81 | CASP6 (0.48) | PDK1CASP6HCAR3ALDH1A1KMT2A | |
| SCHEMBL8303776 | 0.77 | ATM (0.65) | CASP6HCAR3CES2CES1ALDH1A1 | |
| SCHEMBL8300884 | 0.74 | CASP6 (0.49) | CASP6HCAR3CES2CES1ALDH1A1 | |
| SCHEMBL8305961 | 0.73 | ALDH1A1 (0.50) | CASP6HCAR3CES2CES1ALDH1A1 | |
| SCHEMBL8304450 | 0.72 | CASP6 (0.47) | PDK1CASP6HCAR3CES2CES1 | |
| SCHEMBL8305931 | 0.72 | KDM4E (0.57) | CASP6HCAR3CES2CES1ALDH1A1 | |
| SCHEMBL8305888 | 0.71 | CASP6 (0.53) | CASP6HCAR3CES2CES1ALDH1A1 | |
| SCHEMBL8442696 | 0.71 | ALDH1A1 (0.48) | CASP6HCAR3ALDH1A1KMT2ALMNA | |
| SCHEMBL4833667 | 0.71 | CASP6 (0.56) | CASP6HCAR3ALDH1A1KMT2ALMNA | |
| SCHEMBL9188252 | 0.69 | CASP6 (0.57) | CASP6HCAR3ALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |