Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7553115 | 0.86 | PDE4D (0.39) | ALDH1A1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL8310246 | 0.85 | DYRK1A (0.35) | DYRK1ALMNATHRBCTSV | |
| SCHEMBL3701217 | 0.84 | ACACA (0.43) | ALDH1A1MAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL8445339 | 0.82 | BACE1 (0.40) | ALDH1A1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL5615531 | 0.80 | ALDH1A1 (0.43) | ALDH1A1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL5615614 | 0.78 | KMT2A (0.41) | ALDH1A1HSD17B10MAPTMEN1KMT2A | |
| SCHEMBL14607589 | 0.78 | POLB (0.40) | ALDH1A1HSD17B10MAPTCYP3A4KDM4E | |
| SCHEMBL29375169 | 0.78 | PRKDC (0.41) | ALDH1A1HSD17B10MAPTCYP3A4KDM4E | |
| SCHEMBL2456236 | 0.78 | PRKDC (0.41) | ALDH1A1HSD17B10MAPTCYP3A4KDM4E | |
| SCHEMBL5615321 | 0.78 | SMN1; SMN2 (0.43) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0954761-A4 | — | — | 1999-11-10 | — | — | EP | disclosed |
| EP-0954761-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG Industries Ohio, Inc. (US) | 1999-11-10 | — | — | EP | disclosed |
| US-5744070-A | Photochromic substituted naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1998-04-28 | — | — | US | disclosed |
| WO-1997022895-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1997-06-26 | — | — | WO | disclosed |