Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 2/20 | 0.32 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314523 | 0.87 | KMT2A (0.38) | CCR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL8314804 | 0.84 | SIGMAR1 (0.43) | SMN1; SMN2POLBP2RX7KMT2AALDH1A1 | |
| SCHEMBL8312314 | 0.84 | SMN1; SMN2 (0.38) | SMN1; SMN2POLBP2RX7MEN1KMT2A | |
| SCHEMBL8875291 | 0.84 | POLB (0.39) | CCR1SMN1; SMN2POLBP2RX7KMT2A | |
| SCHEMBL8312553 | 0.82 | ALDH1A1 (0.40) | SMN1; SMN2MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL8314253 | 0.82 | KMT2A (0.36) | CCR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL9536076 | 0.80 | SMN1; SMN2 (0.38) | SMN1; SMN2POLBMEN1KMT2AGAA | |
| SCHEMBL8312908 | 0.79 | KMT2A (0.45) | SMN1; SMN2POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL8313857 | 0.79 | KMT2A (0.35) | CCR1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL8317735 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2POLBP2RX7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |